Cardiac Heme Oxygenase 1 (HO‐1) mRNA expression in inbred rat strains after severe hemorrhage

Cardiac mitochondrial proteomic expression in inbred rat strains divergent in survival time after hemorrhage.

We have previously identified inbred rat strains differing in survival time to a severe controlled hemorrhage (StaH). In efforts to identify cellular mechanisms and ultimately genes that are important contributors to enhanced STaH, we conducted a study to characterize potential differences in cardiac mitochondrial proteins in these rats. Inbred rats from three strains [Brown Norway/Medical Coll...

heme oxygenase-1 mrna expression in egyptian patients with chronic liver disease

Genetic influences on survival time after severe hemorrhage in inbred rat strains.

To find a genetic basis for differential ability to survive severe hemorrhage, we previously showed eightfold differences in survival times among inbred rat strains. We assumed that rat strains had similar normalized blood volumes (NBV; ml/100 g body wt). As NBV might vary among strains and constitute one genetic variable affecting survival time to hemorrhage, in experiment 1 of the current stu...

Targeting heme oxygenase after intracerebral hemorrhage.

Intracerebral hemorrhage (ICH) is the primary event in approximately 10% of strokes, and has higher rates of morbidity and mortality than ischemic stroke. Experimental evidence suggests that the toxicity of hemoglobin and its degradation products contributes to secondary injury that may be amenable to therapeutic intervention. Hemin, the oxidized form of heme, accumulates in intracranial hemato...

CALL FOR PAPERS Mitochondrial Metabolism Cardiac mitochondrial proteomic expression in inbred rat strains divergent in survival time after hemorrhage

Harold G. Klemcke, Robert M. DeKroon, Mihaela Mocanu, Jennifer B. Robinette, and Oscar Alzate U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas; Systems Proteomics Core Laboratory, University of North Carolina, Chapel Hill, North Carolina; Program of Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, North Carolina; and Department of Cell and Develop...